CureYourBody.com is excited to announce the launch of
its new forums. The next several months will be critical to setting up the
forums the way you want them to be. So
if you feel we should add more categories or sub forums, please let us know.
We'll add sub forums on our own as well, if we feel a
large number of posts are being made on a specific topic. For example, "Colon Cleansing" was added as a sub forum to the Gastroenterology forum since there seems
to be a lot of posts for that specific subject.
Diabetes mellitus may be classified into two types:
[1] Type I: Absolute insulin deficiency, where insulin treatment is necessary for survival.
- 5-10% of all diabetic patients
- Onset typically in childhood (before age 20), but can occur at any age
- Pathology: autoimmune destruction of beta-cells (insulin-secreting cells in pancreas); develops in genetically-susceptible individuals who are exposed to an environmental factor that triggers autoimmune response
- Overt diabetes mellitus does not appear until about 90% of beta-cells are destroyed
[2] Type II: Insulin resistance (early) or relative insulin deficiency (late), where control of blood glucose levels may be achieved by lifestyle changes or oral therapy, although insulin may also be used to improve control (especially late in disease).
- 90% of all diabetic patients
- Insulin levels usually normal to high, but may diminish over many years of having diabetes
- Insulin Resistance (usually secondary to obesity) plays a major role (lends credence to connotation of "diabesity")
- Goes undiagnosed for many years
- Risk Factors: Obesity, Genetics, Age (insulin production, like all other hormones decreases production with age)
- Pathology: obesity increases plasma levels of free fatty acids, which make muscles more insulin resistant, reducing glucose uptake (therefore obesity exacerbates insulin resistance); in liver free fatty acids increase production of glucose - however, fail to stimulate pancreatic insulin secretion, hyperglycemia (high blood sugar) develops, beta-cells become more desensitized to glucose, leading to decreased insulin secretion
